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KMID : 0381320010400010017
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Korean Journal of Occupational Health
2001 Volume.40 No. 1 p.17 ~ p.28
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Molecular and Cellular Biology of Lung Injury induced by Mineral Fibres
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Tsuda, Tohru
Morimoto, Yasuo/Yamato, Hiroshi/Fujino, Akihiro/Hori, Hajime/Kido, Masamitsu/Higashi, Toshiaki
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Abstract
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The primary concern of our study is to elucidate the development and pathophysiological
Wu J, XU X Cancer mechanisms of occupational and environmental lung disease The results of these studies are
. ,s metalt urg;pl applied in the field of occupational health Therefore, particular focuses are; 1) To introduce
25:913-917. molecular-biomarkers into the risk assessment system of occupational exposed particles, 2)
and cluar yiM. To apply moleailar-biomarkers into conventional research methods, for the purpose of
Encyclopaedia of preventing and detecting early effects caused by occupational exposure to particles.
r 4th ed. Geneva. IIA. II Among fibrous materials, asbestos has been shown to cause diseases such as asbestosis,
lung cancer and mesothelioma On the other hand, there are many industries utilizing´
I asbestos because of the many advantages as an industrial resource: The attempt to replace
on caused by
1;212;546-547. asbestos by man-made mineral fibres (M Ws) is fast in `making progress because the
f of oxygen radical industrial and economic gains we becoming certain
phargocyte-induced MMFs are thought to possess the same adverse biological effects as asbestos because of
2; 2&2Z70-2= their similar physiochemical pres. Current data are now available showing that the new
bu, Zarflcower II UWs are not all nuisance particulate. No epidemiological studies are involving MMFs, and
al aspects of chronic the re: ,11ts of animal studies on the adverse effects of MMFs are conflicting. Moreover, the
mice. 1/rrviron Res toxic potentials of MWs developed most are recently not always understood
Asia is a region which depends heavily on industrial development to sustain its growing
3g o G, Wrnkelmann R´ population Risk assessment of M1VIl~s is a justifiable strategy to adopt particularly in this
ty of wosicers region.
´ during the period We have been constructing the risk assessment system of UWs along following steps:
ion of Italy. Scan J study of physicochemical properties (1). in vitro study, intratracheal instillation study and
12118-123. acute to chronic inhalation study. We have compared the results of these steps with
´I individual step and reached the final decision of toxicity to human
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